This study sought to determine the responses in circulating APN, MMP-2, MMP-3 and OPN—key proteins involved in the remodelling of adipose tissue (Wu et al. 2017; Goncalves et al. 2015; Kahles et al. 2014; Sheikh et al. 2022; Unamuno et al. 2021; Akra et al. 2020)—following two different exercise formats in individuals with overweight or obesity. The gene discussed is SPP1; the disease is obesity due to melanocortin 4 receptor deficiency.