Therefore, we set out to elucidate mechanisms by which FGF21 beneficially modulates these various aspects of NASH in HFCD-fed APOE*3-Leiden.CETP mice, a well-established model for diet-induced NASH (Morrison et al., 2015; Liang et al., 2014). This evidence concerns the gene CETP and metabolic dysfunction-associated steatohepatitis.