Our observations may likely explain the recent clinical findings that treatment with FGF21 analogues in patients with NASH not only reduced hepatic steatosis (Sanyal et al., 2019; Harrison et al., 2021) but also increased hepatic bile acid synthesis and further promoted cholesterol removal, lowering the risk for further hepatic lipotoxicity (Luo et al., 2022). The gene discussed is FGF21; the disease is metabolic dysfunction-associated steatohepatitis.