HFCD feeding induced an array of inflammatory effects, including increased lobular inflammation, hepatocyte ballooning and NAFLD activity scores, as well as increased inflammatory foci and CLSs, accompanied by a reduction in ResKCs with a relative increase in CD11c+ ResKCs, and an increase in MoDMacs and CD11c+ MoKCs. Here, ITGAX is linked to metabolic dysfunction-associated steatotic liver disease.