In CSCs of various human cancers, several HSP family members including HSP70‐1A [19], dnaJ‐B8 [21], HSP90 [30], glucose‐regulated protein of 78‐kDa (GRP78) [31], and HSP27 [32], are overexpressed and considered to play a pivotal role in CSC development and maintenance. This evidence concerns the gene HSPA5 and cancer.