Following the discovery of the leaky RyR2 in failing hearts, we went on to show similar stress-induced leak in skeletal muscle affecting the RyR1 isoform during extreme exercise (49), and also in Duchenne muscular dystrophy (DMD) (24), cancer-associated loss of muscle function (50), age-dependent loss of muscle function (51), and RyR1-RM (22). Here, RYR1 is linked to cancer.