Armed with a generous grant from the Defense Advanced Research Projects Agency, we were able to show that RyR2 channels became leaky in a murine model of PTSD and that either pharmacological (with a Rycal) or genetic (using the non-leaky RyR2-S2808A mouse) treatments could rescue the cognitive and behavioral deficits classically associated with PTSD in this model (26). The gene discussed is RYR2; the disease is post-traumatic stress disorder.