Work spanning 35 years led to cloning of the channel, which directly led to its identification as the key Ca2+ release channel required for excitation-contraction coupling in muscles, to the discovery of its role in the pathogenesis of human disease including HF and cardiac arrhythmias, to drugging of the channel, and now to elucidation of the structural bases for the pathological leak and the mechanism of action of the Rycal drugs to fix the leak. Here, CA2 is linked to hydrops fetalis.