In case of supraphysiologic OAT activity, potential risks of cancer should also be considered because OAT has been found to be overexpressed in hepatocellular carcinoma (Colnot et al, 2004) and in vivo inhibition of OAT has an antitumor effect in mice (Zigmond et al, 2015). Here, OAT is linked to hepatocellular carcinoma.