To verify whether PFE induced liver injury by damaging the mitochondria and causing lipid metabolism disorders in the livers of mice, mitochondrial morphology was detected, and the typical indicators related to lipid metabolism screened by proteomics were determined, including ABCC3, COX6A1, CPT1A, SLC27A5, NDUFB5, and cytochrome C. Transmission electron microscope analysis showed that, at the ultrastructural level, the mitochondrial number was reduced, and mitochondrial cristae were shortened, broken, or disappeared in the PFE group of mice (Figure 5(a)). The gene discussed is COX6A1; the disease is Disorder of lipid metabolism.