As a proof of concept, we used a Quantikine sandwich ELISA kit (R&D Systems cat #DCCD40) to measure plasma levels of CD40 in 20 individuals with relapsing remitting MS in remission at time of plasma collection (8 male, 12 female; mean age = 44.45 ± 15.51 years) and 20 healthy controls (8 male, 12 female; mean age = 41.84 ± 11.52 years; Supplementary Table S7). This evidence concerns the gene CD40 and relapsing-remitting multiple sclerosis.