BCAM is widely expressed in epithelial, endothelial, hematopoietic and other cell types and has been linked to various human diseases, including gastrointestinal and bladder carcinomas,4, 5, 6, 7, 8 sickle cell anemia,9, 10 polycythemia vera11 and glomerulonephritis.12 Here, BCAM is linked to sickle cell disease.