LAMA5 and sickle cell disease: BCAM1 has also been shown to be phosphorylated by glycogen synthase kinase 3β, casein kinase II and PKA at serines 596, 598 and 621, respectively and the phosphorylation state of BCAM might be a critical factor for adhesion of erythrocytes to LAMA5 in sickle cell anemia.76