BCAM and neoplasm: The present study provides new insights into the role of BCAM in the context of OC, which include the mechanism of BCAM shedding from tumour cells to release sBCAM, the hitherto unknown impact of sBCAM on metastasis‐related biological processes, a comparative functional analysis of sBCAM, BCAM1 and BCAM2 and the discovery of novel functions for BCAM with implications for peritoneal metastasis, including spheroid compaction/dispersion and mesothelial clearance.