In the phase III randomized DREAMseq trial with 265 patients with treatment-naive BRAF-mutant melanoma, a -preliminary analysis revealed that, compared with the sequence of targeted therapy followed by immunotherapy, upfront immunotherapy followed by targeted therapy improved OS, with the 2-year OS rate increasing from 52 to 72% (log-rank p = 0.0095) [71]. The gene discussed is BRAF; the disease is melanoma.