For patients with advanced NSCLC, first-line systemic treatment generally consists of targeted therapy, immunotherapy, cytotoxic chemotherapy, or a chemo-immunotherapy combination depending on the tumor's expression of programmed death-ligand 1 (PD-L1), histology type (squamous versus nonsquamous) and the presence of driver mutations, such as epidermal growth factor receptor (EGFR) activation mutation and anaplastic lymphoma kinase (ALK) translocation. Here, CD274 is linked to non-small cell lung carcinoma.