For instance, the levels of Dnmt1, Dnmt3a and 5-methylcytosine are increased in the brain and spinal cords of ALS patients, and unsurprisingly, global changes in DNA methylation and hydroxymethylation have been observed in postmortem spinal tissue of ALS patients [214, 215]. This evidence concerns the gene DNMT1 and amyotrophic lateral sclerosis.