Pharmacological inhibition of DNA-PKcs with the DNA-PKcs inhibitor NU7441 reduced GSC tumorsphere formation [35] mTORC1/2 inhibitors of KU - 0063794 can inhibit PI3K-Akt-mTOR signaling in glioblastoma and reduce cell proliferation [36]. The gene discussed is PRKDC; the disease is glioblastoma.