In DLB patients, the gene expression level of nAChRα3 was lower than in HC (median = 0.7 (IQR 0.3–0.9)) and in AD (median = 4.6 (IQR 2.3–6.3)) (p < 0.001) (Fig. 2b). This evidence concerns the gene CHRNA3 and Lewy body dementia.