Considering nAChRα4 gene expression, a decrease was observed in both DLB and AD patients compared to HC (DLB vs HC: median 0.3 (IQR 0.2–0.8); AD vs HC: median = 0.0 (IQR 0.0–0.0)), although a significantly lower expression was detected in AD compared to DLB (p = 0.001) (Fig. 2c). Here, CHRNA4 is linked to Alzheimer disease.