CHRNB2 and Alzheimer disease: Respect to HC, nAChRβ2 gene expression was reduced in both DLB and AD patients (DLB vs HC: median = 0.0 (IQR 0.0–0.1); AD vs HC: median = 0.7 (IQR 0.5–0.8)), and significantly lower expression levels were observed in DLB compared to AD (p < 0.001) (Fig. 2e).