In the high-risk group, age, BMI, lymphocyte count, albumin, prealbumin, total cholesterol, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), lactic dehydrogenase (LDH), hydroxybutyrate dehydrogenase (HBDH), direct bilirubin, prothrombin activity (PTA), D-dimer, serum ferritin, C-reactive protein, CD3+ T cells, CD4+ T cells, CD8+ T cells, procalcitonin (PCT), pulmonary bacterial infection, and bacteremia were significantly different between the survival and mortality subgroups (Additional file 1). The gene discussed is TTR; the disease is bacterial infectious disease with sepsis.