Recently, Huang et al. [43] developed a CRG index based on 10 CRGs combined with six well-recognized biomarkers (i.e., KRAS, TP53, SMAD4, BRCA1, BRCA2 and CDKN2A) in PAAD using machine learning procedures. This evidence concerns the gene CDKN2A and pancreatic adenocarcinoma.