Our results revealed that cuproptosis Cluster C with a better OS prognosis had an increased infiltration of antitumor immune components, such as activated CD4 T cells, activated CD8 T cells, gamma delta T cells, eosinophils, immature B cells, macrophages and follicular helper T cells, suggesting an immunoreactive characterization of Cluster C. Nonetheless, subtype C also showed a significantly higher expression of immune checkpoint targets, including CTLA-4, PD-1 and PD-L1, which correlated with the recognition of tumor cells by T cells. Here, CD274 is linked to neoplasm.