SHBG and Hirsutism: A recent Cochrane review of 15 randomised controlled trials (RCT) and 498 participants, reported that lifestyle interventions compared with minimal intervention or usual care, significantly reduces weight (kg) and body mass index (BMI) and improves secondary reproductive outcomes such as free androgen index (FAI), testosterone (T), sex hormone-binding globulin (SHBG) and hirsutism (Ferriman-Gallwey score) [37].