Similar impacts of setmelanotide treatment on HRQOL and hyperphagia burden have also been reported in pediatric and adult patients with other rare genetic diseases of obesity, including POMC and LEPR deficiency, highlighting the clinical utility of setmelanotide for HRQOL in patients with rare genetic diseases of obesity. The gene discussed is POMC; the disease is hyperinsulinemic hypoglycemia, familial, 4.