In the present study we report a multicenter series of adult and pediatric patients presenting with a diffuse oligodendroglioma-like glioma with a FGFR3::TACC3 fusion, without (14 cases) or with (8 cases) features of microvascular proliferation and/or necrosis, in order to better characterize the clinico-pathological, molecular and epigenetic spectrum of these rare gliomas. This evidence concerns the gene TACC3 and glioma.