The molecular characterization of fusion-positive glioma revealed that FGFR3::TACC3 is mutually exclusive with IDH and H3 mutation but it is often associated with TERT promoter mutation and + 7/−10 chromosome copy-number changes and amplification of CDK4 and /or MDM2 [13, 31]. The gene discussed is TACC3; the disease is glioma.