However, another pathogenic variant, PMS2:c.2276-125_2445 + 1584del (which indicates the deletion of 1,879 base pairs [bps] including Exon 14 of PMS2 gene, resulting in the stop codon in eight codons after codon 759 with frameshift mutation) was not detected by the F1CDx test, since the length of the deletion was too large to be detected by a next-generation sequencing (NGS) analysis in a cancer genomic profiling test. Here, PMS2 is linked to cancer.