CRP and acute kidney injury: In the sensitivity analyses, adjusting for first AKI stage, sex, ethnicity, BMI, CRP on admission, pre-existing renal problem and Charlson scores, as detailed in Supplementary Table 1, epoch 2 were less likely to progress to a higher AKI stage (adjusted odds ratio [OR] 0.76, 95% CI 0.70–0.83, p = 0.001), have a higher risk of progression to dialysis within 30 days (adjusted OR 1.52, 95% CI 1.28–1.81, p < 0.001), and were more likely to be referred to ICU (adjusted OR 1.58, 95% CI 1.19–2.11, p = 0.002-Supplementary Table 1).