Aberrant activities of many fundamental signaling pathways are responsible for the uncontrol growth and metastasis of NSCLC, including the AMPK, KRAS/RAF/MEK, PI3K/AKT/mTOR, and JAK-STAT pathways (Ashrafizadeh et al. 2021a, b; Herbst et al. 2018; Rotow and Bivona 2017). This evidence concerns the gene PRKAA1 and non-small cell lung carcinoma.