Interestingly, data mining in the COSMIC database revealed that EP300-R1627W was found not only in TCC BCa in our study, but also in B-cell lymphoma, T-cell lymphoma-leukemia, colon adenocarcinoma, endometrial carcinoma, serous carcinoma, malignant melanoma, and gastric adenocarcinoma. The gene discussed is EP300; the disease is melanoma.