PKD2 and autosomal dominant polycystic kidney disease: SCD is caused by a specific pathogenic variant in the HBB gene while ADPKD is most commonly caused by variants in PKD1 or PKD2. Despite the relatively high prevalence of these conditions (ADPKD affects approximately 1 in 1000 people; SCD occurs in approximately 1 out of every 365 Black individuals [1, 2]), the co-occurrence of these two conditions does not appear to have been previously reported.