A handful of studies have reported the co-occurrence of ADPKD and sickle cell trait (SCT), the presence of a single pathogenic variant in the HBB gene, along with variants in either PKD1 or PKD2. The first report, in 1994, noted that the onset of kidney failure occurred approximately 10 years earlier in Black people with both ADPKD and SCT, compared to ADPKD alone [3]. Here, PKD2 is linked to autosomal dominant polycystic kidney disease.