Quantitative comparisons of gene expression from DNA effectors between AD and control individuals (Con) revealed significant differences in expression of the writers DNMT1 (p = 0.01) and DNMT3A (p < 0.05) in the STG and DNMT3B (p < 0.05) in the WM (Fig. 1C, Supplementary Table 8). This evidence concerns the gene DNMT3A and Alzheimer disease.