Therefore, the aim of the present study was to assess the involvement of CAIII and CAIX in the local crosstalk between the tumor adipose microenvironment and ACC, starting from the evaluation of the reciprocal expression of these enzymes in the metabolic alterations of the adipose tissue characterizing obesity and which may be shared by the adipose niche surrounding ACC. The gene discussed is CA9; the disease is adrenal cortex carcinoma.