Thus, we evaluated if this interaction may also exert any effect on CAIII and CAIX expression in both cell compartments, by assessing the reciprocal modulation of the two CAs in an in vitro coculture system set up between ASCs and the two adrenocortical cancer cell lines, H295R and MUC-1 cells. Here, MUC1 is linked to adrenal cortex carcinoma.