Moreover, using an in vitro dynamic coculturing system between adipose precursors and the two adrenocortical cancer cell lines, H295R and MUC-1 [14], we further elucidated a reciprocal modulation of these two enzymes in the crosstalk occurring between ACC and its visceral adipose microenvironment, being the altered expression of CAIII and IX occurring in the adipose microenvironment similar to what we found in VAT in obesity. This evidence concerns the gene CA3 and adrenal cortex carcinoma.