Interestingly, genetic variations in LRP5 intronic rs4988319 and rs3736228 (Ala1330Val) were observed among young females, whereas LRP6 rs2302685 (Val1062Ile) variations were observed in young males, indicating a potential sex-specific link between LRP5 and LRP6 gene variants in ADHD. This evidence concerns the gene LRP6 and attention deficit-hyperactivity disorder.