Importantly, this study shows that NE can affect the secretion of the chemokine CXCL9 and the immunosuppressive metabolite ADO in tumour cells by regulating the WNT7A/β-catenin signalling pathway, thereby reducing the chemotaxis and function of CD8+ T cells, resulting in anti-PD-1 mAb resistance. Here, CXCL9 is linked to neoplasm.