Overall, we observed that (i) symptomatic individuals had less peptides recognized and smaller Ab responses (both IgM and IgG) than asymptomatic and severe cases, (ii) number of recognized epitopes by IgM was relatively more important in asymptomatic individuals witnessing the kinetics of an earlier stage of infection, and (iii) the number of IgG-specific epitopes was relatively more important in severe patients suggesting a longer infection period or a higher viral load exposure. This evidence concerns the gene CD40LG and infection.