SIRT1 and Sepsis: During this process, checkpoint kinase 1 (CHK1) activation phosphorylates p53 and undergoes p300/CBP-mediated acetylation at K373 and/or K382, triggering autophagy and autophagy-mediated IKKα degradation.116 Furthermore, SIRT1-mediated p53 deacetylation promotes autophagy and alleviates sepsis-induced acute kidney injury.117