KDM4B and colorectal carcinoma: Through direct demethylation at the promoters of LC3B, JMJD2B promotes autophagy to benefit protein degradation and recycling to maintain intracellular amino acids, which is critical for CRC cell survival under glucose deprivation conditions.78 Furthermore, in castration-resistant prostate cancer (CRPC), enhanced KDM4B depends on its demethylating activity to activate autophagy by regulating Wnt/β-catenin signaling, leading to CRPC cell proliferation79 (Fig. 2e).