EZH2 and cancer: For example, microRNA-638 and microRNA-92b increase autophagy and apoptosis and suppress cancer cell invasion and migration by targeting EZH2.69,70 miR-124 is capable of inducing autophagic cell death in tumors and alleviates autophagy-mediated diabetic peripheral neuropathy by directly targeting the EZH2-signal transducer and activator of transcription 3 (STAT3) signaling axis.71,72 In contrast, miR-101 directly interacts with EZH2 and downregulates its expression, resulting in autophagy inhibition73,74 (Fig. 2c).