EZH2 and neoplasm: As a result, the expression of mTOR pathway inhibitory genes is suppressed, which elicits mTOR activity and leads to autophagy inhibition.66 On the other hand, autophagy is triggered by EZH2 inhibition to serve as a possible pro-survival mechanism of residual tumor cells with high mobility group A2 (HMGA2) as the critical mediator.67 EZH2 is a repressive modulator of HMGA2.