However, in lung cancer cells, the SIRT1/2-specific inhibitor salermide upregulates pro-survival autophagy via HSPA5 acetylation and subsequent activation of activating transcription factor 4 (ATF4) and DNA damage inducible transcript 4 (DDIT4) to inhibit the mTOR signaling pathway.195. The gene discussed is ATF4; the disease is lung carcinoma.