SQSTM1 and vascular disorder: The histone demethylase LSD1/KDM1A manipulates autophagy directly regulating autophagy-related genes expressions, including ATGs, Beclin-1, LC3 and SQSTM1/p62, it also regulating the activities of some other autophagic signaling proteins such as p53, SESN2, mTORC1 and PTEN, which is implicated in tumors, vascular disorder and inflammation.