EP300 and Sepsis: In particular, p300- and SIRT1-regulated Beclin1 acetylation at the K430 and K437 sites is associated with tumor development,124 sensitivity impairment to anticancer drugs125 and sepsis-induced acute kidney injury/cardiac dysfunction.126,127 SIRT1 or SIRT6 overexpression deacetylates Beclin1 and activates autophagy.