FTH1 and diabetic cardiomyopathy: JQ1 activates mitophagy via PINK1/Parkin, helping improve mitochondrial function and ameliorate diabetic cardiomyopathy.208 Also, JQ1 is able to induce ferroptosis, where ferritinophagy (a process characterized by increased autophagy and iron levels) is required to enhance cell death.209 In this process, JQ1-mediated autophagy degrades ferritin heavy chain 1 (FTH1), leading to enhanced intracellular iron and ROS levels.