G9a/ Euchromatic histone lysine methyltransferase 1 (EHMT2) catalyzes methylation of histone 3 at lysine 9 (H3K9me1, H3K9me2, and H3K9me3) and is frequently overexpressed in various cancers, including glioma, gastric cancer, and lung cancer.48–50 G9a/EHMT2 overexpression was significantly associated with autophagy suppression. Here, EHMT2 is linked to central nervous system cancer.