On the one hand, EZH2 inhibition-triggered autophagy induces cell death of cancer cells62,63 and aortic vascular smooth muscle cells,64 liver injury65 and also helps bacterial elimination.57 In cancer cells, metastasis-associated 1 family member 2 (MTA2) first recognizes unmodified H3 with its SANT domain, then recruits EZH2 to a set of mTOR pathway-related genes, such as TSC2, RHOA, and DEPTOR, which are negative regulators of the mTOR signaling pathway, resulting in increased H3K27me3 accompanied by reduced H3K27ac at the promoters. The gene discussed is DEPTOR; the disease is cancer.