A cell-based screen has found that a potent and highly selective ULK1 kinase inhibitor, SBI-0206965, suppresses ULK1-mediated phosphorylation events by decreasing Beclin1 and VPS34 phosphorylation, upregulating autophagy level and inducing tumor cell apoptosis.221 PIKfyve kinase inhibitors, such as WX8, can disrupt lysosome function in autophagy and selectively kill certain cancer cells. The gene discussed is BECN1; the disease is neoplasm.