It can directly interact with the promoters of core autophagy genes, such as LC3B, TP53INP2/DOR, and WIPI1, increasing their histone methylation levels to reduce autophagy levels.51 In particular, in breast cancer cells, G9a cooperates with DNMT1 to collectively inhibit Beclin1 transcription.52 Chemical inhibition of G9a dissociates H3K9me2 from the Beclin1 promoter and recruits RNA polymerase II and nuclear factor kappa B (NF-κB) to its promoter for transcriptional activity. This evidence concerns the gene TP53INP2 and breast cancer.