Ubiquitylation of p62 disrupts dimerization of the UBA domain of p62, liberating its ability to recognize polyubiquitylated cargoes for selective autophagy.150 Moreover, p62 can be also ubiquitinated by Keap1/Cullin3, with the modified site at K420 within its UBA domain to promote p62’s association with LC3 and autophagy.151 SPOP mutation is frequently mutated in prostate cancer. The gene discussed is SQSTM1; the disease is prostate cancer.