Li et al. constructed a hypoxia-responsive nanoparticle based on gold nanorods that carried a CRISPR/Cas9 system to target HSP90α for knockdown.244 After the vector entered the tumor cells, Cas9/sgRNA RNP was released into the cells, silencing HSP90α and causing the cells to lose their thermotolerance. Here, HSP90AA1 is linked to neoplasm.