Encapsulation of the CRISPR-dCas9-VP64 system into AML12-derived exosomes successfully activated the expression of hepatocyte nuclear factor 4α (HNF4α), a transcriptional regulator of hepatocyte differentiation, in HSCs and a mouse model of liver fibrosis, thereby significantly attenuating liver fibrosis. The gene discussed is HNF4A; the disease is Hepatic fibrosis.