Cancer, a disease with high incidence and mortality rates, is standardly treated using surgical resection, radiotherapy, and chemotherapy; however, the latter two treatments engender serious side effects.239 The process of cancer development is usually accompanied by abnormal expression of large numbers of genes, such as P53, Notch, and PD-L1.240–243 In addition, the microenvironment in which tumorigenesis occurs also exhibits some abnormal changes. This evidence concerns the gene CD274 and cancer.