RPI-1 also has remarkable efficacy in MTC xenografts by facilitating tumor cell apoptosis and inhibiting angiogenesis.376 The results demonstrated that RET oncogene activity is closely related to the maintenance and survival of MEN2A-type MTC, which contributed to the further administration of RPI-1 in treating thyroid cancer with RET alternation. The gene discussed is RET; the disease is medullary thyroid gland carcinoma.