NVP-AST487 is another novel RET tyrosine kinase inhibitor that can also inhibit KDR, Flt-4, Flt-3, c-Kit, and c-Abl.377 The effect of NVP-AST487 was identified in vivo in medullary thyroid cancer with oncogenic RET. This evidence concerns the gene RET and medullary thyroid gland carcinoma.