TP53 and cancer: P73 is related to the tumorigenesis, angiogenesis, and progression of multiple cancers, including HNC.125–127 Unlike TP53, the TP73 gene is rarely mutated.128,129 The TAp73 isoform affects tumor cell apoptosis and growth arrest instead of the ΔNp73 isoform.130,131 The tumor suppressor activity of TAp73 is restrained.