PIK3CA and neoplasm: The HGF/MET pathway is supposed to crosstalk with other signaling pathways, including the PI3K/AKT pathway, MEK/ERK pathway, STAT pathway and Wnt pathway, to promote tumor progression.104,105 The crosstalk between the HGF/MET pathway and the EGFR pathway and VEGFR pathway contributes to therapeutic resistance.104