TP63 and neoplasm: ΔNp63 is the predominant p63 isoform, which is vital for tumorigenesis and progression and senescence suppression and is associated with poor OS in HNC.120–122 P63 is considered a stem cell marker.123 Moreover, ΔNp63 affects the growth factor signaling pathway and tumor metabolic microenvironment through hyaluronic acid signaling and a transcriptional program.124