However, EGFR is overexpressed in ~80% of HNSCC cases and is closely related to poor prognosis.28 EGFR binds with HER family ligands involving epidermal growth factor (EGF), heparin binding-EGF, amphiregulin, transforming growth factor-alpha (TGF-α), epiregulin, and betacellulin, leading to a signal transduction cascade thereby promoting tumor proliferation, invasion, angiogenesis and metastasis and determining the outcomes of diseases.29 Approaches to activate EGFR are multitudinous in head and neck cancer. The gene discussed is EGF; the disease is head and neck cancer.