The effect of BGJ398 in HNSCC was closely related to the expression of FGFR in vivo.290 Furthermore, the selective FGFR inhibitor PD173074 alone also resulted in a remarkable response in an HNSCC xenograft model.291 AZD4547 is another novel inhibitor with a potent ability to inhibit FGFR1, FGFR2 and FGFR3, which could promote the effect of radiotherapy in an HNSCC patient-derived xenograft model.292. This evidence concerns the gene FGFR3 and head and neck squamous cell carcinoma.