The non-pathogenic E. coli strain MG1655 was observed to target tumor cells due to the high production of TNF-α from E. coli strains, specifically within tumors, which may provide a potential platform for tumor therapy.198 Furthermore, immunogenic intestinal bacteria can induce Tfh-related antitumor immune responses in colon cancer tissues, demonstrating a potential therapeutic method for colorectal cancer.101. This evidence concerns the gene TNF and neoplasm.