Rubinstein and colleagues found that Fusobacterium adheres to and invades epithelial and colorectal cancer cells through surface virulence factor-FadA bound to E-cadherin.82 Adhesion of FadA leads to phosphorylation of E-cadherin on the cell membrane and subsequently internalization of E-cadherin through clathrin. The gene discussed is CDH1; the disease is colorectal cancer.