Intratumoral-resident microbiota, including Lachnoclostridium, EBV, HBV, and MCPyV could induce chemokine production and further affect CD8+ T cell infiltration in tumor tissues, consequently improving patient survival in cutaneous melanoma.95–99 The abundance of Bifidobacterium was increased and localized intratumorally by the induction of high-salt diet, leading to enhanced NK cell function and melanoma regression through the elevated by-product-hippurate.100. This evidence concerns the gene CD8A and neoplasm.