CD8A and pancreatic adenocarcinoma: For instance, the presence of Saccharopolyspora, Pseudoxanthomonas, and Streptomyces in pancreatic adenocarcinoma tissues may contribute to antitumor immune responses by favoring the recruitment and activation of CD8+ T cells.43 Higher densities of CD8+ T and granzyme+ B cells were detected in long-term survival patients compared to those in short-term survival patients; no significant differences were found in macrophages, regulatory T cells (Tregs), and myeloid-derived suppressor cells (MDSCs).