RHOA and neoplasm: Bacteria in tumor cells can inhibit the RhoA/ROCK signaling pathway, resulting in adaptation of circulating tumor cells to fluid shear stress by adjusting the cytoskeleton and promoting distant colonization.87 In ovarian cancer, it has been found that TAGLN can induce tumor progression by upregulating the RhoA/ROCK pathway in tumor cells when stimulated by environmental stiffness.156