Furthermore, the densities of CD8+ T and granzyme B+ cells were found to have a close relationship with tumor tissues and the overall survival of pancreatic adenocarcinoma patients.43 Wang et al.94 recently reported that trimethylamine N-oxide (TMAO) secreted by the genera under Clostridiales could trigger the protein kinase-like ER kinase (PERK)-mediated endoplasmic reticulum (ER) stress, which enhances antitumor immunity and improve the efficacy of immunotherapy in triple-negative breast cancer induced by tumor cell pyroptosis. This evidence concerns the gene CD8A and pancreatic adenocarcinoma.