We classified the cohorts according to the clinical information and found that SERPINE2 expression was significantly higher in the tissues with metastasis (p = 0.038) (Fig. 6C) and a higher Fuhrman grade (p = 0.0091) (Fig. 6D) or tumor stage (p = 0.0076) (Fig. 6E) based on the IHC score. This evidence concerns the gene SERPINE2 and neoplasm.