More importantly, scRNA-seq identified SERPINE2 as a gene participating in the metastasis process, and hierarchical chromatin organization comparison showed that SERPINE2 was highly-expressed in RCC as a differential expressed gene (DEG) which could potentially predict metastasis, suggesting that it may prove to be a novel target to advanced or metastatic RCC. The gene discussed is SERPINE2; the disease is renal cell carcinoma.