Selected hits block lactateproduction in cells and inhibit pancreatic cancer cell lines withcytotoxicity IC50 down to 12.26 μM against MIAPaCa-2cells and 14.64 μM against PANC-1, which, under normoxic conditions,is already comparable or more potent than most currently availableknown LDHA inhibitors. This evidence concerns the gene LDHA and familial pancreatic carcinoma.