For example, SIRT1 was found to protect human neuroblastoma SH-SY5Y cells by downregulating the expression of NF-κB and cleaved poly(ADP-ribose) polymerase 1 and by reducing the formation of phospho-α-Syn aggregates, whereas SIRT2 promoted toxic protein aggregation by deacetylating α-Syn and α-tubulin, thereby exacerbating the pathogenesis of PD (28). This evidence concerns the gene SIRT2 and Parkinson disease.