Whereas in type 1 diabetes mellitus (T1DM) patients, poor metabolic control alters the GH/IGF-1 (growth hormone/Insulin-like growth factors-1) axis, whereas higher urine magnesium excretion may signal modest changes in renal function and/or glucosuria that result in smaller and less dense bones [26]. The gene discussed is IGF1; the disease is type 1 diabetes mellitus.