IGHE and infection: In humans, naturally occurring polymorphisms in FCER1 are known to affect an individual’s serum IgE levels, with consequences for their susceptibility to infection (Weidinger et al., 2008; Granada et al., 2012) and their risk of developing inflammatory disease (Hasegawa et al., 2003; Potaczek et al., 2006; Zhou et al., 2012; Niwa et al., 2010).