MAPT and amyotrophic lateral sclerosis: Binding in the CSTs of 2-([1E,3E]-4-[6-([11C]methylamino)pyridinyl]buta-1,3-dienyl)benzo[d]thiazol-6-ol ([11C]PBB3), a tau radiotracer, was shown to correlate with upper motor neuron signs in a patient with ALS/parkinsonian dementia complex overlap; however, extensive reports of tau agents are lacking at the current time, although an attractive target given the pathologic findings of TDP-43 in ALS [222, 232].