Although the magnitude of the change of expression between normal and tumor appears greater for PCA3 than for PRUNE2 in both cohorts (Figure 1A and Figure 3A), we attribute this to the reciprocal nature of the comparison, in conjunction with the very low level of normal prostatic PCA3 expression as compared with the higher expression of PRUNE2 in normal prostate. This evidence concerns the gene PRUNE2 and neoplasm.