Thus, these results in mouse together with observations of MCT1 expression alterations in human neurodegenerative disease (Lee et al., 2012; Andres Benito et al., 2018; Tang et al., 2019), strongly point to MCT1-dependent bioenergetic loss as causative for neuronal function alterations and neurodegeneration. The gene discussed is SLC16A1; the disease is neurodegenerative disease.