Overexpression of nuclear protein FK506‐binding protein 3 (FKBP3) and histone deacetylase 2 (HDAC2) could promote L‐OHP resistance in CRC cells, whereas knockdown of FKBP3 could abate L‐OHP resistance by decreasing HDAC2 expression and perhaps through regulating PTEN/AKT pathway in CRC cells.47 Here, PTEN is linked to colorectal carcinoma.