HIF1A and colorectal carcinoma: Zebularine, a low‐toxicity DNA methyltransferase (DNMT) inhibitor, could overcome hypoxia‐induced CDDP resistance in HCT116 cells and show the same efficacy in HCT116 xenograft models and AOM/DSS‐induced CRC mouse models by downregulating HIF‐1α expression through hydroxylation.88