Suppression of Src homology 3‐domain GRB2‐like protein 1 (SH3GL1) could reverse the 5‐FU resistance in a multitude of CRC cell lines including HT29/5‐FU, HCT116/5‐FU, LoVo/5‐FU, and HCT8/5‐FU cell lines through downregulating MDR1/P‐gp via the EGFR/ERK/activator protein‐1 (AP‐1) pathway.37 This evidence concerns the gene PGP and colorectal carcinoma.