RNAi of kallikrein 11 (KLK11) that is correlated with malignant behaviors of CRC can overcome L‐OHP resistance by inducing apoptosis and evading cell growth by suppressing the PI3K/AKT signaling pathway in L‐OHP‐resistant HCT‐8/L‐OHP cell line.40 The gene discussed is KLK11; the disease is colorectal carcinoma.