It was reported that the combined use of aspirin (a nonselective COX inhibitor) and 5‐FU could reverse drug resistance and potentiate the antineoplasm effect of 5‐FU by abolishing 5‐FU‐induced nuclear factor‐kappaB (NF‐κB) activation in 5‐FU‐resistant SW480, SW620 (SW480/5‐FU and SW620/5‐FU) cell lines and xenograft mice of CRC.9 This evidence concerns the gene NFKB1 and colorectal carcinoma.