Knockdown of circ_0007031 could repress tumor malignant progression and reverse 5‐FU resistance in HCT116/5‐FU and SW480/5‐FU cell lines via regulating ATP‐binding cassette subfamily C member 5 (ABCC5) expression by sponging miR‐133b.80 The gene discussed is ABCC5; the disease is neoplasm.