Wawro et al. found that both aspirin and ibuprofen inhibit the VCR‐dependent secretion of tumor growth factor‐βs (TGF‐βs) and interleukin‐6 (IL‐6) from cancer‐associated fibroblasts (CAFs) in CAF‐like cells, suggesting that aspirin and ibuprofen may reverse VCR‐resistance in CRC to some extent.10 This evidence concerns the gene IL6 and colorectal carcinoma.