ARBs block AT1 leading to the likely activation of AT2 receptors in the brain.29 AT1 activation increases oxidative stress, neuroinflammation, endothelial dysfunction, and reduced cerebral perfusion.30 AT2 activation produces anti-inflammatory effects that can be neuroprotective,31 including inhibition of cerebral ischemia.32 Previous studies report that ARBs can reduce cerebrovascular inflammation resulting in neuroprotective effects. This evidence concerns the gene AGTR2 and brain ischemia.