We observed an overexpression of TNF-α, IL-6, IL-22, IL-23, and IL-17 family cytokines (IL-17A, IL-17E, and IL-17F) in mannan-induced psoriasis-skin inflammation, suggesting their contribution to the inflammatory processes in the affected skin, similar to the reported role of these cytokines in IISI [7]. The gene discussed is IL17F; the disease is psoriasis.