Consequently, the targets including Caspase-3 (CASP3), estrogen receptor 1 (ESR1), phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit α (PIK3CA), epidermal growth factor receptor (EGFR), tumor necrosis factor (TNF), and amyloidβ (A4) precursor protein (APP) played fundamental role in the treatment of NAFLD. This evidence concerns the gene PIK3CA and metabolic dysfunction-associated steatotic liver disease.