SLC5A2 and type 2 diabetes mellitus: According to the Guyton hypothesis, sodium and water excretion are key determinants of BP (Guyton, 1987), so our data are also consistent with clinical trials that have demonstrated only a modest reduction in BP with SGLT2 inhibitors, despite inducing glycosuria (Kinaan et al., 2017), and a failure to promote natriuresis in T2DM patients over 2 weeks (Scholtes et al., 2021).