We do not believe our results reflect RAAS activation because urinary aldosterone excretion is not increased in this pre‐nephropathy T1DM model (Culshaw et al., 2019), and in T1DM patients angiotensin II and plasma renin activity are reduced (Feldt‐Rasmussen et al., 1987; Thomsen & Shirley, 1997). Here, REN is linked to type 1 diabetes mellitus.