In addition, protein modification with linear ubiquitin chains (LUBAC) plays a crucial role in the oncogenic activation of NF-κB in ABC DLBCL cells because LUBAC attaches linear polyubiquitin chains to IκB kinase-γ, an indispensable element for the function of NF-κB (Yang et al., 2014). The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.