However, in our study, using DLBCL patient tissues and cell lines, we found that CENPF affected the immune microenvironment of DLBCL by altering ubiquitination modifications through proteomic and ubiquitinomic analyses, and we hope to identify the mechanism by which CENPF affects the prognosis of DLBCL and provide promising therapeutic strategies for DLBCL. Here, CENPF is linked to diffuse large B-cell lymphoma.