We found that CENPF was positively correlated with CD8+ T cells, NK cells and B lymphocytes in DLBCL, while it tended to be negatively correlated with CD4+ T cells, so we suggest that CENPF may induce immune dysregulation by mediating protein deubiquitination in multiple immune pathways. The gene discussed is CD8A; the disease is diffuse large B-cell lymphoma.