Regarding the effects of the FKN/CX3CR1 axis on the hyperexcitability and neurodegeneration associated with epilepsy, FKN is increased in the pilocarpine-induced status epilepticus (SE) rat model [105, 131, 133, 136], contributing to microglial activation, hyperexcitability, and neurodegeneration. This evidence concerns the gene CX3CL1 and epilepsy.