The FKN expression is reduced in the putamen of patients with Huntington's Disease (HD) [101] and in R6/1 HD transgenic mice [101], which has been mechanistically confirmed by the finding that huntingtin reduces the levels of FKN in the StHdhQ111 immortalized embryonic striatal cell line [127] and the striatum of R6/2 HD transgenic mice [128]. This evidence concerns the gene HTT and Huntington disease.