VSIG4 and Hypertension: In addition, VSIG4 expression was remarkably higher among patients who had a history of hypertension (P < 0.05), cardiogenic diseases (P < 0.05), and palpitations (P < 0.05); smokers (P < 0.05); patients aged >60 years (P < 0.05); females (P < 0.05).