SOD activity in the kidneys of rats receiving 100 mg/kg and 200 mg/kg of polyphenolic extract was significantly lower than in subjects with MetS and receiving a standard diet (4.89 ± 0.80 U/mg, p = 0.0087 and 4.53 ± 1.41, p = 0.0043 vs. 7.38 ± 1.21 U/mg, respectively). This evidence concerns the gene SOD1 and metabolic syndrome.