For example, necdin protects neurons by promoting mitochondrial biogenesis [100], LARP7 protects against heart failure by enhancing mitochondrial biogenesis [96], doxycycline reduces weight gain in early breast cancer patients by inhibiting mitochondrial biogenesis in mammary stem cells [101], and PGRN prevents diabetic nephropathy by inhibiting mitochondrial biogenesis [102]. The gene discussed is LARP7; the disease is breast carcinoma.