NF-κB is regulated by a variety of cytokines, such as RANKL, IL-1, and TNF- α, and occupies a central position in osteolytic diseases such as periprosthetic osteolysis and arthritis, and the use of NF-κB modulators provides new ideas for the treatment of related diseases [57]. This evidence concerns the gene TNFSF11 and arthritic joint disease.